Cas No.: 70-18-8 L-Glutathione Skin Whitening Anti-allergy
L—glutathione can be synthesised from the amino acids glycine, L-glutamic acid and L-cysteine. GSH exists in two forms namely, glutathione disulfide (GSSG) and glutathione (GSH) with former being the common form.
The presence of GSH induces the production of pheomelanin (light coloured pigment for skin whitening and fairness) and suppresses the production of eumelanin (darker brown/black pigment).
Being an ingredient of skin whitening products it inhibits melanin synthesis by interrupting L-DOPA’s abilility to bind to enzyme
Tyrosinase (monophenol monooxygenase). Glutathione induces inhibition of tyrosinase glycosylation. This blocks the maturation as well as transfer of tyrosinase from Golgi-endoplasmic recticulum-lysosome (GERL) - coated vesicles to the premelanosome. GSH is believed to direct tyrosinase inactivation within the enzyme’s active site by chelating copper. As glutathione takes part in the conversion of dopaquinone to pheomelanin, it mediates in the transformation of eumelanogenesis to pheomelanogenesis. Its antioxidant properties help to neutralyze the peroxides and free radicals which induce melanin synthesis.
White crystalline powder
Free soluble in water, very slightly soluble in ethanol
Appearance of solution
Clear and Colorless
Loss on Drying
Specific Optical Rotation
Heavy Metal , mg/kg
Radiation sickness and radiation safety: radiation, radioactive substances or because of leukopenia caused by anticancer drugs and other symptoms can play a protective effect.
To protect the liver, detoxification, inactivation of hormones, and to promote bile acid metabolism and help absorb fat and fat-soluble vitamins digestive tract.
Anti-allergy, or inflammation caused by hypoxemia in patients with systemic or local, can reduce cell damage and promote repair.
Easy to speed up the metabolism of acids in the excretion of free radicals, which play a beauty skin care, anti-aging effect.
5.Small samples free
Glutathione as a systemic skin whitening agent via the buccal mucosa: an open-label, single-arm study
Joyce Castillo, MD, Ramiro Community Hospital, Tagbilaran City, Philippines; Evangeline Handog, MD, Asian Hospital and Medical Center, Muntinlupa, Philippines; Ivan Singzon, MD, St Luke’s Medical Center Global City, Taguig, Philippines; Maria Suzanne Datuin, MD, St Luke’s Medical Center Global City, Taguig, Philippines Background: Skin color is the most apparent phenotypic variation among humans and is primarily determined by the type and amount of melanin synthesized within melanosomes and the pattern of melanosome distribution within the melanocytes. In the Philippines and in most parts of Asia, behavior favoring a lighter skin color has driven the development of a lot of skin whitening products, making it one of the most common forms of body modification practices in the world. Objective: To determine whether glutathione administered through the buccal mucosa at 500 mg per day for 12 weeks is effective and safe as a skin whitening agent. Methods: This open-label, single arm study. Thirty-six otherwise healthy female medical secretaries and hospital personnel with Fitzpatrick skin type IV or V received 500 mg of glutathione daily for 12 weeks administered through the buccal mucosa. The main outcome was mean reduction of melanin indices measured at a sun-exposed area (extensor right wrist) and sun-protected area (mid-sternum) after 12 weeks. The melanin indices were measured again after discontinuing the glutathione for 4 weeks (at week 16). Secondary outcomes were the mean change in melanin indices at 4-week intervals in sun-exposed vs sun-protected areas and abnormalities, if any, in the blood counts and liver enzymes at the end of the study. Statistical significance was determined using t-test. Results: Thirty-four participants completed the study out of thirty-six enrolled subjects. There was a significant decrease in melanin index evident at 4 weeks (for sun-exposed area) and 8 weeks (sun-protected area). The reduction in melanin index is significantly higher in the sun-exposed area that in the sun-protected site. Four weeks after discontinuing glutathione, melanin indices continued to decrease significantly. No serious adverse events were reported and laboratory examinations remained normal. Conclusion: Glutathione administered via the buccal mucosa is an effective and safe method of skin lightening in a small number of Filipino females. The effect is evident even after 4 weeks of discontinuation. However, long-term safety has not been established and placebo-controlled clinical trials are warranted.
TAG:   L-Glutathione WHITENING ANTI-AGING